Diosmin for Antioxidant

Diosmin for Antioxidant

Diosmin is a naturally occurring flavonoid glycoside belonging to the flavonoid family, with the chemical name 3′,5,7-trihydroxy-4′-methoxyflavone-7-rutinoside (CAS No. 520-27-4). It is widely distributed in plant sources such as citrus fruits, bitter oranges, and in Chinese medicinal herbs like Aurantii Fructus Immaturus (zhishi) and Sophorae Japonicae Flos (huaimi). Commercially, it is primarily produced through standardized plant extraction or biosynthesis, ensuring high purity (typically ≥98%) and consistent bioactivity for pharmaceutical, nutraceutical, and functional food applications.
Core Biological Activities & Mechanisms
Diosmin is best known for its potent venotonic and vasculoprotective properties, supported by extensive preclinical and clinical research:
Venous Tone Enhancement: It strengthens the walls of veins and capillaries, improving venous return and reducing blood stasis—key for addressing chronic venous insufficiency (CVI) and varicose veins.
Microcirculation Improvement: By regulating capillary permeability and reducing edema, it alleviates symptoms like leg heaviness, swelling, and discomfort associated with poor circulation.
Anti-inflammatory & Antioxidant Effects: It inhibits pro-inflammatory mediators (e.g., TNF-α, IL-6) and scavenges free radicals, protecting vascular endothelial cells from oxidative damage and reducing inflammation in conditions like hemorrhoids.
Lymphatic Circulation Support: It promotes lymphatic drainage, further aiding in edema reduction and tissue fluid balance.
Key Applications
Pharmaceuticals: As an active pharmaceutical ingredient (API), it is formulated into tablets, capsules, and oral solutions. And it is used for treating chronic venous insufficiency, hemorrhoids (acute and chronic), and lymphatic edema. It is also used in combination with hesperidin (a synergistic flavonoid) to enhance efficacy.
Nutraceuticals & Dietary Supplements: Marketed as a functional ingredient for cardiovascular health, it targets consumers seeking natural solutions for vein support.
Functional Foods & Beverages: Incorporated into fortified foods, herbal teas, and health drinks, leveraging its natural origin and well-documented safety profile.
Cosmetics: Emerging applications in skincare products. It has antioxidant properties and ability to improve microcirculation, reducing dark circles and puffiness.