Diosmin has been widely used since 1969 as a phlebotonic and vascular protector for venous leg ulcers and hemorrhoids; however, clinical data to support these uses are limited. Most, but not all available clinical data support its use for chronic venous insufficiency (CVI) and hemorrhoid disease, both acute and chronic. Diosmin has also been used to improve postoperative cardiac function and outcomes in adults undergoing coronary artery bypass grafting (CABG) surgery, for pelvic congestion caused by pelvic varicose veins in men and women, and for varicoceles in men; however, few large-scale quality clinical trials support these uses.
| Certificate of Analysis | |
|---|---|
| Physical Description | |
| Appearance | White or White Like Powder |
| Odor | Characteristic |
| Taste | Characteristic |
| Bulk Density | 50-60g/100ml |
| Particle Size | 95%-99% through 80 mesh |
| Chemical Tests | |
| Hesperidin | ≥90% 95% |
| Loss on Drying | ≤1.0% |
| Ash | ≤1.0% |
| Total Heavy Metals | ≤10 ppm |
| Cadmium (Cd) | ≤1 ppm |
| Mercury (Hg) | ≤1 ppm |
| Lead (Pb) | ≤2 ppm |
| Arsenic (As) | ≤2ppm |
| Microbiology Control | |
| Aerobic Bacterial Count | ≤1,000 cfu/g |
| Total Yeast & Mold | ≤100 cfu/g |
| Escherichia Coli | Negative |
| Salmonella | Negative |
| Staphlococcus Aureus | Negative |
